Article
Three-dimensional behavioural phenotyping of freely moving C. elegans using quantitative light field microscopy.
PloS one - 1 Jan 2018
Shaw Michael, Zhan Haoyun, Elmi Muna, Pawar Vijay, Essmann Clara, Srinivasan Mandayam A
Abstract excerpt
Behavioural phenotyping of model organisms is widely used to investigate fundamental aspects of organism biology, from the functioning of the nervous system to the effects of genetic mutations, as well as for screening new drug compounds. However, our capacity to observe and quantify the full range and complexity of behavioural responses is limited by the inability of conventional microscopy techniques to capture...
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