Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis.

doi:10.1080/08820139.2018.1480033

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Article

Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis.

Immunological investigations - 1 Oct 2018

Najafi Shamsolmoulouk, Mohammadzadeh Mahsa, Rajabi Fateme, Zare Bidoki Alireza, Yousefi Hila, Farhadi Elham, Rezaei Nima

Abstract excerpt

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral condition with a major impact on the quality of life. The condition is thought to be due to the overexpression of T helper-1(Th1)-related cytokines. Since interleukin-4 (IL-4) and its receptor (IL-4Rα) are antagonistic to Th-1 pathw...

Topics

Alleles
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-4
Interleukin-4 Receptor alpha Subunit
Iran
Male
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Stomatitis, Aphthous
Th1-Th2 Balance

Source

Open in PubMed

Identifiers

PMID: 29985726
DOI: 10.1080/08820139.2018.1480033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-29985726-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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