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Article

Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis.

Immunological investigations - 1 Oct 2018

Najafi Shamsolmoulouk, Mohammadzadeh Mahsa, Rajabi Fateme, Zare Bidoki Alireza, Yousefi Hila, Farhadi Elham, Rezaei Nima

Abstract excerpt

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral condition with a major impact on the quality of life. The condition is thought to be due to the overexpression of T helper-1(Th1)-related cytokines. Since interleukin-4 (IL-4) and its receptor (IL-4Rα) are antagonistic to Th-1 pathways, polymorphisms in their genes may also be involved in the pathogenesis of aphthous stomatitis. METHODS: Sixty-four...

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PMID: 29985726
DOI: 10.1080/08820139.2018.1480033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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