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Article

Early phosphoproteomic changes for adverse outcome pathway development in the fathead minnow (Pimephales promelas) brain.

Scientific reports - 5 Jul 2018

Smith L C, Lavelle C M, Silva-Sanchez C, Denslow N D, Sabo-Attwood T

Abstract excerpt

Adverse outcome pathways (AOPs) are conceptual frameworks that organize and link contaminant-induced mechanistic molecular changes to adverse biological responses at the individual and population level. AOPs leverage molecular and high content mechanistic information for regulatory decision-making, but most current AOPs for hormonally active agents (HAAs) focus on nuclear receptor-mediated effects only despite...

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Identifiers

PMID: 29977039
DOI: 10.1038/s41598-018-28395-w
PMCID: PMC6033950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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