Article
Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen-free rhesus macaque (Macaca mulatta) colony based on massively parallel sequencing.
Journal of medical primatology - 1 Dec 2018
Kanthaswamy Sreetharan, Oldt Robert F, Ng Jillian, Smith David Glenn, Martínez Melween I, Sariol Carlos A
Abstract excerpt
BACKGROUND: Knowledge of major histocompatibility complex (MHC) composition and distribution in rhesus macaque colonies is critical for management strategies that maximize the utility of this model for biomedical research. METHODS: Variation within the Mamu-A and Mamu-B (class I) and DRB, DQA/B, and DPA/B (class II) regions of 379 animals from the Caribbean Primate Research Center's (CPRC) specific pathogen free...
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