Article
Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.
Nature communications - 27 Jun 2018
Talebi Ali, Dehairs Jonas, Rambow Florian, Rogiers Aljosja, Nittner David, Derua Rita, Vanderhoydonc Frank, Duarte Joao A G, Bosisio Francesca, Van den Eynde Kathleen, Nys Kris, Pérez Mónica Vara, Agostinis Patrizia, Waelkens Etienne, Van den Oord Joost, Fendt Sarah-Maria, Marine Jean-Christophe, Swinnen Johannes V
Abstract excerpt
Whereas significant anti-tumor responses are observed in most BRAFV600E-mutant melanoma patients exposed to MAPK-targeting agents, resistance almost invariably develops. Here, we show that in therapy-responsive cells BRAF inhibition induces downregulation of the processing of Sterol Regulator Element Binding (SREBP-1) and thereby lipogenesis. Irrespective of the escape mechanism, therapy-resistant cells...
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