Article
Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment.
Nature - 1 Jan 2000
Monaco A P, Bertelson C J, Middlesworth W, Colletti C A, Aldridge J, Fischbeck K H, Bartlett R, Pericak-Vance M A, Roses A D, Kunkel L M
Abstract excerpt
The Duchenne muscular dystrophy (DMD) locus has been localized to the short arm of the human X chromosome (Xp21) by detection of structural abnormalities and by genetic linkage studies. A library highly enriched for human DNA from Xp21 was constructed using DNA isolated from a male patient who ha...
Topics
- Alleles
- Chromosome Aberrations
- Chromosome Deletion
- Chromosome Disorders
- Cloning, Molecular
- DNA Restriction Enzymes
- Female
- Genetic Carrier Screening
- Humans
- Male
- Muscular Dystrophies
- Sex Factors
- X Chromosome