Article
Pigmentation abnormalities in nucleotide excision repair disorders: Evidence and hypotheses.
Pigment cell & melanoma research - 1 Jan 2019
Kasraian Zeinab, Trompezinski Sandra, Cario-André Muriel, Morice-Picard Fanny, Ged Cécile, Jullie Marie-Laure, Taieb Alain, Rezvani Hamid Reza
Abstract excerpt
Skin pigmentation abnormalities are manifested in several disorders associated with deficient DNA repair mechanisms such as nucleotide excision repair (NER) and double-strand break (DSB) diseases, a topic that has not received much attention up to now. Hereditary disorders associated with defective DNA repair are valuable models for understanding mechanisms that lead to hypo- and hyperpigmentation. Owing to the...
Topics
- Animals
- DNA Damage
- DNA Repair
- Humans
- Models, Biological
- Phenotype
- Pigmentation Disorders