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Article

CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective.

British journal of anaesthesia - 1 Jul 2018

Klenke S, de Vries G J, Schiefer L, Seyffert N, Bachmann H S, Peters J, Frey U H

Abstract excerpt

BACKGROUND: Clinical risk factors for postoperative nausea and vomiting (PONV) are evaluated with the Apfel score, however patients with low Apfel scores still experience PONV suggesting a genetic predisposition. PONV risk associates with specific M3 muscarinic acetylcholine receptor (CHRM3) rs 2165870 polymorphism. We investigated whether the Apfel score and this genetic variation independently contribute to...

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Source

Identifiers

PMID: 29935595
DOI: 10.1016/j.bja.2018.02.025

Genes

CHRM3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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