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Article

Accuracy of Different Bioinformatics Methods in Detecting Antibiotic Resistance and Virulence Factors from Staphylococcus aureus Whole-Genome Sequences.

Journal of clinical microbiology - 1 Sept 2018

Mason Amy, Foster Dona, Bradley Phelim, Golubchik Tanya, Doumith Michel, Gordon N Claire, Pichon Bruno, Iqbal Zamin, Staves Peter, Crook Derrick, Walker A Sarah, Kearns Angela, Peto Tim

Abstract excerpt

In principle, whole-genome sequencing (WGS) can predict phenotypic resistance directly from a genotype, replacing laboratory-based tests. However, the contribution of different bioinformatics methods to genotype-phenotype discrepancies has not been systematically explored to date. We compared three WGS-based bioinformatics methods (Genefinder [read based], Mykrobe [de Bruijn graph based], and Typewriter [BLAST...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29925638
DOI: 10.1128/JCM.01815-17
PMCID: PMC6113501

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