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Article

MicroRNA-guided prioritization of genome-wide association signals reveals the importance of microRNA-target gene networks for complex traits in cattle.

Scientific reports - 19 Jun 2018

Fang Lingzhao, Sørensen Peter, Sahana Goutam, Panitz Frank, Su Guosheng, Zhang Shengli, Yu Ying, Li Bingjie, Ma Li, Liu George, Lund Mogens Sandø, Thomsen Bo

Abstract excerpt

MicroRNAs (miRNA) are key modulators of gene expression and so act as putative fine-tuners of complex phenotypes. Here, we hypothesized that causal variants of complex traits are enriched in miRNAs and miRNA-target networks. First, we conducted a genome-wide association study (GWAS) for seven functional and milk production traits using imputed sequence variants (13~15 million) and >10,000 animals from three dairy...

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Identifiers

PMID: 29921979
DOI: 10.1038/s41598-018-27729-y
PMCID: PMC6008395

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