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Article

Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension.

The Journal of physiology - 1 Feb 2019

Hu Cheng-Jun, Zhang Hui, Laux Aya, Pullamsetti Soni S, Stenmark Kurt R

Abstract excerpt

Chronic pulmonary hypertension (PH) is characterized by the accumulation of persistently activated cell types in the pulmonary vessel exhibiting aberrant expression of genes involved in apoptosis resistance, proliferation, inflammation and extracellular matrix (ECM) remodelling. Current therapies for PH, focusing on vasodilatation, do not normalize these activated phenotypes. Furthermore, current approaches to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29920674
DOI: 10.1113/JP275857
PMCID: PMC6375873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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