Article
Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context.
Nature communications - 15 Jun 2018
Ben-Shachar Rotem, Koelle Katia
Abstract excerpt
An extensive body of theory addresses the topic of pathogen virulence evolution, yet few studies have empirically demonstrated the presence of fitness trade-offs that would select for intermediate virulence. Here we show the presence of transmission-clearance trade-offs in dengue virus using viremia measurements. By fitting a within-host model to these data, we further find that the interaction between dengue and...
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