Article
Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes.
Blood advances - 26 Jun 2018
Ali Abdullah Mahmood, Huang Yumin, Pinheiro Ronald Feitosa, Xue Fumin, Hu Jingping, Iverson Nicholas, Hoehn Daniela, Coutinho Diego, Kayani Jehanzeb, Chernak Brian, Lane Joseph, Hillyer Christopher, Galili Naomi, Jurcic Joseph, Mohandas Narla, An Xiuli, Raza Azra
Abstract excerpt
Anemia is the defining feature in most patients with myelodysplastic syndromes (MDS), yet defects in erythropoiesis have not been well characterized. We examined freshly obtained bone marrow (BM) samples for stage-specific abnormalities during terminal erythroid differentiation (TED) from 221 samples (MDS, n = 205 from 113 unique patients; normal, n = 16) by measuring the surface expression of glycophorin A, band...
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