Article
Culture-independent Profiling of the Fecal Microbiome to Identify Microbial Species Associated with a Diarrheal Outbreak in Immunocompromised Mice.
Comparative medicine - 1 Aug 2018
Misic Ana M, Miedel Emily L, Brice Angela K, Cole Stephen, Zhang Grace F, Dyer Cecilia D, Secreto Anthony, Smith Abigail L, Danet-Desnoyers Gwenn, Beiting Daniel P
Abstract excerpt
Immunocompromised mice are used frequently in biomedical research, in part because they accommodate the engraftment and study of primary human cells within a mouse model; however, these animals are susceptible to opportunistic infections and require special husbandry considerations. In 2015, an outbreak marked by high morbidity but low mortality swept through a colony of immunocompromised mice; this outbreak...
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