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Article

Vex-seq: high-throughput identification of the impact of genetic variation on pre-mRNA splicing efficiency.

Genome biology - 1 Jun 2018

Adamson Scott I, Zhan Lijun, Graveley Brenton R

Abstract excerpt

Understanding the functional impact of genomic variants is a major goal of modern genetics and personalized medicine. Although many synonymous and non-coding variants act through altering the efficiency of pre-mRNA splicing, it is difficult to predict how these variants impact pre-mRNA splicing. Here, we describe a massively parallel approach we use to test the impact on pre-mRNA splicing of 2059 human genetic...

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Identifiers

PMID: 29859120
DOI: 10.1186/s13059-018-1437-x
PMCID: PMC5984807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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