Article
Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design.
Journal of neuro-oncology - 1 Sept 2018
Everson Richard G, Hashimoto Yuuri, Freeman Jacob L, Hodges Tiffany R, Huse Jason, Zhou Shouhao, Xiu Joanne, Spetzler David, Sanai Nader, Kim Lyndon, Kesari Santosh, Brenner Andrew, De Monte Franco, Heimberger Amy, Raza Shaan M
Abstract excerpt
INTRODUCTION: Surgery and radiation therapy are the standard treatment options for meningiomas, but these treatments are not always feasible. Expression profiling was performed to determine the presence of therapeutic actionable biomarkers for prioritization and selection of agents. METHODS: Meningiomas (n = 115) were profiled using a variety of strategies including next-generation sequencing (592-gene panel:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.