Article
Cigarette smoke induces DNA single-strand breaks in human cells.
Nature - 1 Jan 2000
Nakayama T, Kaneko M, Kodama M, Nagata C
Abstract excerpt
Epidemiological evidence suggests that smoking is a major cause of human lung cancer. However, the mechanism by which cigarette smoke induces the cancer remains obscure, although in tobacco carcinogenesis, promotion and/or co-carcinogenesis may have crucial roles. The epidemiological data show that if an individual stops smoking, the risk of his contracting lung cancer increases no further. Moreover, laboratory...
Topics
- Cells, Cultured
- DNA
- Humans
- Hydrogen Peroxide
- Hydroxides
- Mutation
- Oxygen
- Plants, Toxic
- Smoke
- Superoxides
- Nicotiana