Article
Cigarette smoke induces DNA single-strand breaks in human cells.
Nature - 1 Jan 2000
Nakayama T, Kaneko M, Kodama M, Nagata C
Abstract excerpt
Epidemiological evidence suggests that smoking is a major cause of human lung cancer. However, the mechanism by which cigarette smoke induces the cancer remains obscure, although in tobacco carcinogenesis, promotion and/or co-carcinogenesis may have crucial roles. The epidemiological data show that if an individual stops smoking, the risk of his contracting lung cancer increases no further. Moreover, laboratory...
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