Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids

29 May 2018

Abstract excerpt

Keloids are a type of abnormal scar tissue. MicroRNAs (miRNAs) exhibit a pivotal role in the regulation of cell proliferation and metastasis of keloids. miRNA microarray revealed that miR‑637 was one of the most frequently altered miRNAs in keloids. Furthermore, up-regulation of miR‑637 inhibited cell proliferation and metastasis by targeting mothers against decapentaplegic homolog (Smad)3, one of the important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatologic Treatments and Research
Share to Kruppel-like factors research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29845237
DOI: 10.3892/mmr.2018.9099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloidsPMID 29845237Read ↗

micro RNA deregulation in keloids: an opportunity for clinical intervention?Semantic proximity Read ↗

MiR-21 Regulates Keloid Formation by Downregulating Smad7 via the TGF-β/Smad Signaling PathwaySemantic proximity Read ↗

Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblastsSemantic proximity Read ↗

Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathwaySemantic proximity Read ↗

Epigenetic modification mechanisms involved in keloid: current status and prospectSemantic proximity Read ↗

Identification and analysis of dysregulated lncRNA and associated ceRNA in the pathogenesis of keloidSemantic proximity Read ↗

miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloidsSemantic proximity Read ↗

Endothelial‐to‐mesenchymal transition induced by W nt 3a in keloid pathogenesisSemantic proximity Read ↗

Long non-coding RNA HOXA11-AS accelerates the progression of keloid formation via miR-124-3p/TGFβR1 axis.Semantic proximity Read ↗

Keloids – clinical diagnosis, pathogenesis, and treatment optionsSemantic proximity Read ↗

MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.Semantic proximity Read ↗

Keloid pathogenesis and fibroproliferative properties are dependent on stem cells regulated by the HEDGEHOG-GLI1 pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.