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Candida albicans Aro1 affects cell wall integrity, biofilm formation and virulence.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Feb 2020

Yeh Ying-Chieh, Wang Hung-Yen, Lan Chung-Yu

Abstract excerpt

BACKGROUND: Candida albicans is an opportunistic pathogen capable of causing life-threatening systemic infections. The C. albicans ARO1 gene encodes an arom multifunctional enzyme, which can possibly catalyze reactions of the shikimate pathway to synthesize aromatic amino acids. However, the functions of C. albicans Aro1 have not been extensively characterized. METHODS: ARO1 knockdown mutant strain was...

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PMID: 29807722
DOI: 10.1016/j.jmii.2018.04.002

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