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Demographic History and Genetic Adaptation in the Himalayan Region Inferred from Genome-Wide SNP Genotypes of 49 Populations.

Molecular biology and evolution - 1 Aug 2018

Arciero Elena, Kraaijenbrink Thirsa, Asan, Haber Marc, Mezzavilla Massimo, Ayub Qasim, Wang Wei, Pingcuo Zhaxi, Yang Huanming, Wang Jian, Jobling Mark A, van Driem George, Xue Yali, de Knijff Peter, Tyler-Smith Chris

Abstract excerpt

We genotyped 738 individuals belonging to 49 populations from Nepal, Bhutan, North India, or Tibet at over 500,000 SNPs, and analyzed the genotypes in the context of available worldwide population data in order to investigate the demographic history of the region and the genetic adaptations to the harsh environment. The Himalayan populations resembled other South and East Asians, but in addition displayed their...

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PMID: 29796643
DOI: 10.1093/molbev/msy094
PMCID: PMC6063301

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