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Article

Identification of small-molecule EGFR allosteric inhibitors by high-throughput docking.

Future medicinal chemistry - 1 Jul 2018

Caporuscio Fabiana, Tinivella Annachiara, Restelli Valentina, Semrau Marta S, Pinzi Luca, Storici Paola, Broggini Massimo, Rastelli Giulio

Abstract excerpt

AIM: The EGFR inhibitors represent the first-line treatment of non-small-cell lung cancer. However, the emergence of resistance urgently requires the development of new inhibitors targeting drug-resistant mutants. METHODOLOGY: A recently released structure of an EGFR kinase domain in complex with an allosteric inhibitor and a mutant protein model derived from it were used to set up a low-cost high-throughput...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29766737
DOI: 10.4155/fmc-2018-0063

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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