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Article

Treatment-resistant depression and peripheral C-reactive protein.

The British journal of psychiatry : the journal of mental science - 1 Jan 2019

Chamberlain Samuel R, Cavanagh Jonathan, de Boer Peter, Mondelli Valeria, Jones Declan N C, Drevets Wayne C, Cowen Philip J, Harrison Neil A, Pointon Linda, Pariante Carmine M, Bullmore Edward T

Abstract excerpt

BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not...

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PMID: 29764522
DOI: 10.1192/bjp.2018.66
PMCID: PMC6124647

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