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Article

Normal serum protein electrophoresis and mutated IGHV genes detect very slowly evolving chronic lymphocytic leukemia patients.

Cancer medicine - 1 Jun 2018

Chauzeix Jasmine, Laforêt Marie-Pierre, Deveza Mélanie, Crowther Liam, Marcellaud Elodie, Derouault Paco, Lia Anne-Sophie, Boyer François, Bargues Nicolas, Olombel Guillaume, Jaccard Arnaud, Feuillard Jean, Gachard Nathalie, Rizzo David

Abstract excerpt

More than 35 years after the Binet classification, there is still a need for simple prognostic markers in chronic lymphocytic leukemia (CLL). Here, we studied the treatment-free survival (TFS) impact of normal serum protein electrophoresis (SPE) at diagnosis. One hundred twelve patients with CLL were analyzed. The main prognostic factors (Binet stage; lymphocytosis; IGHV mutation status; TP53, SF3B1, NOTCH1, and...

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Share to Blood Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis

Share to High-Throughput Nucleotide Sequencing

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Metastasis

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Source

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Identifiers

PMID: 29745034
DOI: 10.1002/cam4.1510
PMCID: PMC6010869

Genes

NOTCH1

Provenance

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