Article
An Outbreak of Streptococcus pyogenes in a Mental Health Facility: Advantage of Well-Timed Whole-Genome Sequencing Over emm Typing.
Infection control and hospital epidemiology - 1 Jul 2018
Bergin Sarah M, Periaswamy Balamurugan, Barkham Timothy, Chua Hong Choon, Mok Yee Ming, Fung Daniel Shuen Sheng, Su Alex Hsin Chuan, Lee Yen Ling, Chua Ming Lai Ivan, Ng Poh Yong, Soon Wei Jia Wendy, Chu Collins Wenhan, Tan Siyun Lucinda, Meehan Mary, Ang Brenda Sze Peng, Leo Yee Sin, Holden Matthew T G, De Partha, Hsu Li Yang, Chen Swaine L, de Sessions Paola Florez, Marimuthu Kalisvar
Abstract excerpt
OBJECTIVEWe report the utility of whole-genome sequencing (WGS) conducted in a clinically relevant time frame (ie, sufficient for guiding management decision), in managing a Streptococcus pyogenes outbreak, and present a comparison of its performance with emm typing.SETTINGA 2,000-bed tertiary-care psychiatric hospital.METHODSActive surveillance was conducted to identify new cases of S. pyogenes. WGS guided...
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