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CIC‐NUTM1 fusion: A case which expands the spectrum of NUT ‐rearranged epithelioid malignancies

27 Apr 2018

Abstract excerpt

NUT carcinoma (NC) shows very aggressive clinical behavior, occurs predominantly in the thorax and head and neck region of children and adults, and is defined by the presence of NUT (aka NUTM1) rearrangement, mostly BRD4-NUTM1 fusion resulting from t(15;19)(q13; p13.1). So-called "NUT variants" harbor alternate fusions between NUTM1 and BRD3, NSD3, ZNF532, or unknown partners. Rare cases of pediatric tumors with...

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PMID: 29700887
DOI: 10.1002/gcc.3

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