Article
Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.
Acta neuropathologica - 1 Sept 2018
Portelius Erik, Olsson Bob, Höglund Kina, Cullen Nicholas C, Kvartsberg Hlin, Andreasson Ulf, Zetterberg Henrik, Sandelius Åsa, Shaw Leslie M, Lee Virginia M Y, Irwin David J, Grossman Murray, Weintraub Daniel, Chen-Plotkin Alice, Wolk David A, McCluskey Leo, Elman Lauren, McBride Jennifer, Toledo Jon B, Trojanowski John Q, Blennow Kaj
Abstract excerpt
Neurogranin (Ng) is a post-synaptic protein that previously has been shown to be a biomarker for synaptic function when measured in cerebrospinal fluid (CSF). The CSF concentration of Ng is increased in Alzheimer's disease dementia (ADD), and even in the pre-dementia stage. In this prospective study, we used an enzyme-linked immunosorbent assay that quantifies Ng in CSF to test the performance of Ng as a marker...
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