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Article

Hepatitis B Virus X protein elevates Parkin-mediated mitophagy through Lon Peptidase in starvation

22 Apr 2018

Abstract excerpt

Hepatocellular Carcinoma (HCC) is the fifth most prevalent cancer worldwide. Specially, Hepatitis B viurs X protein (HBx) is a leading factor in the progression of Hepatitis B viurs-related HCC. Nutrient-deprived tumor microenvironment also contributes to tumor development. However, the role of HBx in nutrient-deprived HCC has received little investigation. Here, we show that HBx elevates PINK1-Parkin mediating...

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PMID: 29689279
DOI: 10.1016/j.yexcr.2018.04.016

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