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Translational regulation of mitochondrial biogenesis

2 Dec 2016

Abstract excerpt

Mitochondria are generated by the expression of genes on both nuclear and mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to cellular energy demand, developmental signals and environmental stimuli. Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis to co-ordinate energy homeostasis with cell growth. The local translation of mitochondrial proteins on the...

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PMID: 27913682
DOI: 10.1042/bst20160071c

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