Article
Dynamic Variation and Reversion in the Signature Amino Acids of H7N9 Virus During Human Infection.
The Journal of infectious diseases - 13 Jul 2018
Zou Xiaohui, Guo Qiang, Zhang Wei, Chen Hui, Bai Wei, Lu Binghuai, Zhang Wang, Fan Yanyan, Liu Chao, Wang Yeming, Zhou Fei, Cao Bin
Abstract excerpt
Background: Signature amino acids of H7N9 influenza A virus play critical roles in human adaption and pathogenesis, but their dynamic variation is unknown during disease development. Methods: We sequentially collected respiratory samples from H7N9 patients at different timepoints and applied next-generation sequencing (NGS) to the whole genome of the H7N9 virus to investigate the variation at signature sites....
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