Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.

doi:10.1210/jc.2017-02646

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Article

Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.

The Journal of clinical endocrinology and metabolism - 1 Jul 2018

Tamura Ai, Ogasawara Tatsuki, Fujii Yoichi, Kaneko Hiyori, Nakayama Akitoshi, Higuchi Seiichiro, Hashimoto Naoko, Miyabayashi Yui, Fujimoto Masanori, Komai Eri, Kono Takashi, Sakuma Ikki, Nagano Hidekazu, Suzuki Sawako, Koide Hisashi, Yokote Koutaro, Iseki Kozue, Oguma Rena, Matsue Hiroyuki, Nojima Hiroyuki, Sugiura Kensuke, Yoshitomi Hideyuki, Ohtsuka Masayuki, Rahmutulla Bahityar, Kaneda Atsushi, Inoshita Naoko, Ogawa Seishi, Tanaka Tomoaki

Abstract excerpt

Context: Necrolytic migratory erythema (NME) occurs in approximately 70% of patients with glucagonoma syndrome. Excessive stimulation of metabolic pathways by hyperglucagonemia, which leads to hypoaminoacidemia, contributes to NME pathogenesis. However, the molecular pathogenesis of glucagonoma and relationships between metabolic abnormalities and clinical symptoms remain unclear. Patient: A 53-year-old woman was...

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PMID: 29688432
DOI: 10.1210/jc.2017-02646

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