Article
Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis.
Journal of gastroenterology and hepatology - 1 Dec 2018
Nimri Lili, Staikin Katerina, Peri Irena, Yehuda-Shnaidman Einav, Schwartz Betty
Abstract excerpt
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic syndrome. Deposition of excess triglycerides in liver cells, a hallmark of NAFLD, is associated with loss of insulin sensitivity. Ostreolysin (Oly) is a 15-kDa fungal protein known to interact with cholesterol-enriched raft-like membrane domains. We aim to test whether a recombinant version of Oly (rOly)...
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