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The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells

28 Mar 2018

Abstract excerpt

BACKGROUND: Human cytomegalovirus (HCMV) establishes a persistent life-long infection and increasing evidence indicates HCMV infection can modulate signaling pathways associated with oncogenesis. Breast milk is an important route of HCMV transmission in humans and we hypothesized that mammary epithelial cells could be one of the main cellular targets of HCMV infection. METHODS: The infectivity of primary human...

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PMID: 29628341
DOI: 10.1016/j.ebiom.2018.03.015

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