Article
NGS combined with phylogenetic analysis to detect HIV-1 dual infection in Romanian people who inject drugs.
Microbes and infection - 1 May 2018
Popescu Bogdan, Banica Leontina, Nicolae Ionelia, Radu Eugen, Niculescu Iulia, Abagiu Adrian, Otelea Dan, Paraschiv Simona
Abstract excerpt
Dual HIV infections are possible and likely in people who inject drugs (PWID). Thirty-eight newly diagnosed patients, 19 PWID and 19 heterosexually HIV infected were analyzed. V2V3 loop of HIV-1 env gene was sequenced on the NGS platform 454 GSJunior (Roche). HIV-1 dual/multiple infections were identified in five PWID. For three of these patients, the reconstructed variants belonged to pure F1 subtype and...
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