Article
Myelodysplastic Syndrome and Sweet's Syndrome Are Associated with a Mutation in Isocitrate Dehydrogenase 1.
Anticancer research - 1 Apr 2018
Snyder Rose, Libby Tiffany, Raciti Patricia, Amin Bijal, Jacobson Mark, Rakheja Dinesh, Fleming Kirsten, Bartenstein Matthias, Zhu Changcheng, Goel Swati, Verma Amit K, Shastri Aditi
Abstract excerpt
BACKGROUND: Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to...
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