Article
BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells.
Haematologica - 1 Jun 2018
Wroblewski Mark, Scheller-Wendorff Marina, Udonta Florian, Bauer Raimund, Schlichting Jara, Zhao Lin, Ben Batalla Isabel, Gensch Victoria, Päsler Sarina, Wu Lei, Wanior Marek, Taipaleenmäki Hanna, Bolamperti Simona, Najafova Zeynab, Pantel Klaus, Bokemeyer Carsten, Qi Jun, Hesse Eric, Knapp Stefan, Johnsen Steven, Loges Sonja
Abstract excerpt
Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1 treatment decreases the numbers of pre-, immature and mature B cells while numbers of early pro-B cells remain...
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