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Article

Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.

American journal of clinical pathology - 29 Mar 2018

Gullo Irene, Batista Rui, Rodrigues-Pereira Pedro, Soares Paula, Barroca Helena, do Bom-Sucesso Maria, Sobrinho-Simões Manuel

Abstract excerpt

OBJECTIVES: Multinodular goiter (MNG) and well-differentiated thyroid carcinoma (WDTC) are emerging phenotypes of DICER1 syndrome. METHODS: Histologic and molecular findings of botryoid-type embryonal rhabdomyosarcoma (bERMS) and thyroid nodules from a 12-year-old DICER1 mutation carrier (p.Arg1060Ilefs*7) were investigated, providing interesting clues for understanding thyroid carcinogenesis. RESULTS: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29538609
DOI: 10.1093/ajcp/aqy004

Genes

DICER1
RET
PAX8
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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