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Article

Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1G93A ALS Mouse Model via Upregulation of D-Amino Acid Oxidase.

Molecular neurobiology - 1 Jan 2018

Lin HuiQian, Hu HaoJie, Duan WeiSong, Liu YaLing, Tan GuoJun, Li ZhongYao, Liu YaKun, Deng BinBin, Song XueQin, Wang Wan, Wen Di, Wang Ying, Li ChunYan

Abstract excerpt

Self-complementary adeno-associated viral vector 9 (scAAV9) has been confirmed to be an efficient AAV serotype for gene transfer to the central nervous system (CNS). Neurotrophic factors have been considered to be therapeutic targets for amyotrophic lateral sclerosis (ALS). In the present study, we intramuscularly injected scAAV9 encoding human insulin-like growth factor 1 (hIGF1) into an hSOD1G93A ALS mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27995572
DOI: 10.1007/s12035-016-0335-z

Genes

IGF1
DAO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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