Article
A validation and extended description of the Lund taxonomy for urothelial carcinoma using the TCGA cohort.
Scientific reports - 27 Feb 2018
Marzouka Nour-Al-Dain, Eriksson Pontus, Rovira Carlos, Liedberg Fredrik, Sjödahl Gottfrid, Höglund Mattias
Abstract excerpt
Global gene expression analysis has been a major tool for urothelial carcinoma subtype discovery. This approach has revealed extensive complexity both in intrinsic features of the tumor cells and in the microenvironment. However, global gene expression cannot distinguish between gene expression signals originating from the tumor cells proper and from normal cells in the biopsy. Here, we use a large cohort of...
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