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Article

Absence of relationship between type-I interferon suppression and neuropathogenicity of EHV-1.

Veterinary immunology and immunopathology - 1 Mar 2018

Oladunni Fatai S, Sarkar Sanjay, Reedy Stephanie, Balasuriya Udeni B R, Horohov David W, Chambers Thomas M

Abstract excerpt

Equine herpesvirus-1 (EHV-1) infection is an important and highly prevalent disease in equine populations worldwide. Previously we have demonstrated that a neuropathogenic strain of EHV-1, T953, suppresses the host cell's antiviral type-I interferon (IFN) response in vitro. Whether or not this is unique to EHV-1 strains possessing the neuropathogenic genotype has been undetermined. Here, we examined whether there...

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PMID: 29475503
DOI: 10.1016/j.vetimm.2018.01.007

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