Article
HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.
Thoracic cancer - 1 Apr 2018
Kumagai Toru, Tomita Yasuhiko, Nakatsuka Shin-Ichi, Kimura Madoka, Kunimasa Kei, Inoue Takako, Tamiya Motohiro, Nishino Kazumi, Susaki Yoshiyuki, Kusu Takashi, Tokunaga Toshiteru, Okami Jiro, Higashiyama Masahiko, Imamura Fumio
Abstract excerpt
BACKGROUND: Activating EGFR mutations, HER2, and HER3 are implicated in lung cancer; however, with the exception of EGFR gene amplification in lung adenocarcinoma harboring EGFR mutations, their involvement in disease progression during the early stages is poorly understood. In this paper, we focused on which receptor is correlated with lung adenocarcinoma progression in the presence or absence of EGFR mutation...
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