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Article

Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

Journal of cancer research and clinical oncology - 1 May 2018

Rechsteiner Markus, Dedes Konstantin, Fink Daniel, Pestalozzi Bernhard, Sobottka Bettina, Moch Holger, Wild Peter, Varga Zsuzsanna

Abstract excerpt

BACKGROUND: The role of somatic BRCA1/2 gene mutations in breast cancer is getting increasing attention in view of hereditary disease. The medullary phenotype and triple negative intrinsic subtypes are often, but not exclusively encountered in BRCA1 germline mutated breast cancer, whilst for BRCA2, no association to specific histological features are known. In this study, we addressed the relationship between...

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Identifiers

PMID: 29453630
DOI: 10.1007/s00432-018-2609-5
PMCID: PMC5916977

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BRCA1
BRCA2

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