Article
Posaconazole MIC Distributions for Aspergillus fumigatus Species Complex by Four Methods: Impact of cyp51A Mutations on Estimation of Epidemiological Cutoff Values.
Antimicrobial agents and chemotherapy - 1 Apr 2018
Espinel-Ingroff A, Turnidge J, Alastruey-Izquierdo A, Dannaoui E, Garcia-Effron G, Guinea J, Kidd S, Pelaez T, Sanguinetti M, Meletiadis J, Botterel F, Bustamante B, Chen Y-C, Chakrabarti A, Chowdhary A, Chryssanthou E, Córdoba S, Gonzalez G M, Guarro J, Johnson E M, Kus J V, Lass-Flörl C, Linares-Sicilia M J, Martín-Mazuelos E, Negri C E, Pfaller M A, Tortorano A M
Abstract excerpt
Estimating epidemiological cutoff endpoints (ECVs/ECOFFS) may be hindered by the overlap of MICs for mutant and nonmutant strains (strains harboring or not harboring mutations, respectively). Posaconazole MIC distributions for the Aspergillus fumigatus species complex were collected from 26 laboratories (in Australia, Canada, Europe, India, South and North America, and Taiwan) and published studies. Distributions...
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