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Article

Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis.

Cell and tissue research - 1 May 2018

Lussey-Lepoutre Charlotte, Buffet Alexandre, Morin Aurélie, Goncalves Judith, Favier Judith

Abstract excerpt

Paragangliomas and pheochromocytomas are rare neuroendocrine tumors characterized by a large spectrum of hereditary predisposition. Based on gene expression profiling classification, they can be classically assigned to either a hypoxic/angiogenic cluster (cluster 1 including tumors with mutations in SDHx, VHL and FH genes) or a kinase-signaling cluster (cluster 2 consisting in tumors related to RET, NF1, TMEM127...

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Source

Identifiers

PMID: 29427052
DOI: 10.1007/s00441-018-2797-y

Genes

MAX
RET
VHL

Provenance

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