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Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

1 Feb 2018

Abstract excerpt

Biofilms provide refuge for cancerous bacteria Familial adenomatous polyposis (FAP) causes benign polyps along the colon. If left untreated, FAP leads to a high incidence of colon cancer. To understand how polyps influence tumor formation, Dejea et al. examined the colonic mucosa of FAP patients. They discovered biofilms containing the carcinogenic versions of the bacterial species Escherichia coli and...

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PMID: 29420293
DOI: 10.1126/science.aah3648

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