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Article

Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism.

Blood pressure - 1 Aug 2018

Maiolino Giuseppe, Ceolotto Giulio, Battistel Michele, Barbiero Giulio, Cesari Maurizio, Amar Laurence, Caroccia Brasilina, Padrini Roberto, Azizi Michel, Rossi Gian Paolo

Abstract excerpt

PURPOSE: Aldosterone-producing adenoma (APA) is the main curable cause of endocrine hypertension cause of primary aldosteronism (PA) and it is in up to 66% of all cases investigated with adrenal vein sampling (AVS). Mutations in the KCNJ5 potassium channel involve up to 70% of APA and cause the most florid PA phenotypes. The recent finding that macrolide antibiotics specifically inhibit in vitro the altered...

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Identifiers

PMID: 29409357
DOI: 10.1080/08037051.2018.1436961

Genes

KCNJ5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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