Article
Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation.
Circulation - 10 Jul 2018
Gladka Monika M, Molenaar Bas, de Ruiter Hesther, van der Elst Stefan, Tsui Hoyee, Versteeg Danielle, Lacraz Grègory P A, Huibers Manon M H, van Oudenaarden Alexander, van Rooij Eva
Abstract excerpt
BACKGROUND: Genome-wide transcriptome analysis has greatly advanced our understanding of the regulatory networks underlying basic cardiac biology and mechanisms driving disease. However, so far, the resolution of studying gene expression patterns in the adult heart has been limited to the level of extracts from whole tissues. The use of tissue homogenates inherently causes the loss of any information on cellular...
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