Article
Mutations in SUFU and PTCH1 genes may cause different cutaneous cancer predisposition syndromes: similar, but not the same.
Familial cancer - 1 Oct 2018
Huq A J, Walsh M, Rajagopalan B, Finlay M, Trainer A H, Bonnet F, Sevenet N, Winship I M
Abstract excerpt
Many cancer predisposition syndromes are preceded or accompanied by a range of typical skin signs. Gorlin syndrome is a rare multisystem inherited disorder which can predispose to basal cell carcinomas (BCCs), childhood medulloblastomas in addition to various developmental abnormalities; the majority of cases are due to mutations in the PTCH1 gene. Approximately 5% of cases have been attributed to a mutation in...
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