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Article

Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

11 Jan 2018

Abstract excerpt

Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation, migration and differentiation. However, when incorporating MSCs within injectable, inherently soft hydrogels, this dominance over MSC response substantially limits our ability to couple the ease of application of hydrogels with efficiently directed MSC...

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PMID: 29343687
DOI: 10.1038/s41467-017-02486-0

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