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Article

Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2018

Jiang Yanan, Du Weijie, Chu Qun, Qin Ying, Tuguzbaeva Gulnara, Wang Hui, Li Anqi, Li Guiyang, Li Yanyao, Chai Lu, Yue Er, Sun Xi, Wang Zhiguo, Pavlov Valentin, Yang Baofeng, Bai Yunlong

Abstract excerpt

BACKGROUND/AIMS: Arsenic trioxide (ATO) is a known anti-acute promyelocytic leukemia (APL) reagent, whose clinical applications are limited by its serious cardiac toxicity and fatal adverse effects, such as sudden cardiac death resulting from long QT syndrome (LQTS). The mechanisms of cardiac arrhythmia due to ATO exposure still need to be elucidated. Long non-coding RNAs (lncRNAs) are emerging as major...

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PMID: 29339628
DOI: 10.1159/000486357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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