MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

doi:10.1073/pnas.1706928115

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Article

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018

Menachery Vineet D, Schäfer Alexandra, Burnum-Johnson Kristin E, Mitchell Hugh D, Eisfeld Amie J, Walters Kevin B, Nicora Carrie D, Purvine Samuel O, Casey Cameron P, Monroe Matthew E, Weitz Karl K, Stratton Kelly G, Webb-Robertson Bobbie-Jo M, Gralinski Lisa E, Metz Thomas O, Smith Richard D, Waters Katrina M, Sims Amy C, Kawaoka Yoshihiro, Baric Ralph S

Abstract excerpt

Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ-dependent genes following infection...

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Identifiers

PMID: 29339515
DOI: 10.1073/pnas.1706928115
PMCID: PMC5798318

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